About HopES Sarcoma Trial

TYME/JAF

HopES Sarcoma Trial

The HopES Sarcoma Trial is seeking patients with Ewing’s sarcoma and advanced sarcoma cancer. Should you be interested in participating in a clinical trial or finding out more about what this trial can do for a loved one, we are happy to help you in your journey.

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I am 18+ and agree to be contacted via phone, text, or email. To be eligible, participants must be 12 years or older and have a diagnosis of Ewing's and advanced sarcoma cancer. Additional study requirements will be discussed with a study representative.

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What is Sarcoma Cancer?

Sarcomas are cancers of the bone and connective tissue. It is made up of many “subtypes” because it can arise from a variety of tissue structures. Nerves, muscles, joints, bone, fat, blood vessels – collectively referred to as the body’s “connective tissues.”

Sarcomas are rare in adults and make up approximately 1% of all adult cancer diagnoses. They are relatively more common among children. Between roughly 1,500 children are diagnosed with a bone or soft tissue sarcoma in the U.S. each year. Ewing’s represents 30% of cancers in children under the age of 30.

Sarcoma Types

Common Signs and Symptoms

What Are Clinical Trials?

Clinical trials are research studies that investigate new treatments or new combinations of treatments. Sarcoma clinical trials are necessary to determine whether new treatments developed in the laboratory are beneficial to people living with Ewing’s and sarcomas cancers. The Food and Drug Administration (FDA) reviews and analyzes data from successful clinical trials to determine whether an experimental treatment should be approved for a specific disease or disorder.

Will I Benefit From Participating?

The study medicine is an investigational cancer metabolism-based compound and you may or may not achieve a clinical benefit. By participating in the HopES Sarcoma Study, you may:

Take an active role in your own healthcare
Contribute to medical research and helping to shape the future of medicine

The HopES Sarcoma Trial applies the latest advances in the field of cancer metabolism by evaluating the efficacy and safety of an oral investigational compound that targets the metabolic mechanisms of the disease at its source. The HopES Sarcoma Trial is designed to evaluate SM-88 (racemetyrosine) for the treatment of high-risk sarcomas, which are ultra-rare cancers with high unmet medical need. TYME Cancer Metabolism-Based Therapies (CMBTs™) are proprietary investigational compounds that are believed to disrupt cancer cells’ protein synthesis, leading to a breakdown of the cancer’s key defenses and cell death.

About TYME SM-88

SM-88 is an oral investigational modified proprietary tyrosine derivative that is believed to interrupt the metabolic processes of cancer cells by breaking down the cells’ key defenses and leading to cell death through oxidative stress and exposure to the body’s natural immune system. Clinical trial data have shown that SM-88 has demonstrated encouraging tumor responses across 15 different cancers, including pancreatic, lung, breast, prostate and sarcoma cancers with minimal serious grade 3 or higher adverse events.

About the Joseph Ahmed Foundation

The Joseph Ahmed Foundation (JAF) is a 501(c)(3) non-profit organization that was founded in 2016 by the family of Joseph Ahmed, who lost his courageous battle with Ewing’s Sarcoma eight months after his diagnosis on September 1, 2014, at the age of 16. Through their tragic loss and grief, Joseph’s loved ones established the Joseph Ahmed Foundation which is dedicated to raising public awareness for the importance of early detection of the disease, and the urgent need of funding for research and development of innovative treatment and therapies to treat Ewing’s Sarcoma and other forms of pediatric cancer. JAF’s mission is to provide resources for research programs and support services through fundraising, philanthropic donations, corporate sponsorship and grants. JAF is comprised of passionate board members and volunteers who all share the same vision, finding a cure.

Clinical Trial Frequently Asked Questions

What is an investigational medication?

An investigational medication has been tested in the laboratory and the U.S. Food and Drug Administration (FDA) is allowing it to be tested in people. It is not approved for sale by the FDA or other government agencies. A clinical trial tests how well an investigational medication works and whether it is safe to use for a specific disease or disorder.

How does a clinical trial evaluating an investigational medication work?

A clinical trial has a structured set of clinic visits, tests, and drug dosing schedule the patient must follow. Information about how you feel and how you are reacting to the study treatment is collected.

How are my rights and safety protected as a patient during a clinical trial?

Protecting the health and safety of people who take part in clinical trials is the highest priority for clinical researchers throughout the entire study process. All clinical trials follow strict federal guidelines on how volunteers must be treated.

How does COVID-19 impact the clinical operations of HopES Sarcoma Trial?

As a result of today’s challenges with COVID-19, and based on the Principal Investigators guidance, eligible patients may be able to take oral SM-88 at home as well as interact with the clinical trial physician through telemedicine remotely. This way we keep all participants in the TYME-88-Panc trial compliant and safe when it comes to COVID-19 guidelines and best practices.

Can I leave the clinical trial before it ends?

You have the right to leave a clinical trial at any time, for any reason. If you decide to leave a trial, talk to your doctor first. You will want to know how leaving the trial might affect your health and what other treatment options may be available.

How can I learn more about the investigational medication and this study?

More information on this clinical trial can be found on clinicaltrials.gov